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VITILIGO NEWS (FEBRUARY 2012)

Is Vitiligo Curable? 

When we have to treat simple sciatica or any simple inflammation and we take medications usually the 10th day or the 15th day we are completely cured. Therefore vitiligo can’t be treated in fifteen (15) days.

If we take a look at the following 40 incidents that show the improvement of vitiligo in a 3 month or 5 month combined (local oral treatment) without laser – phototherapy (difficult, expensive or usually very dangerous treatments) then it’s up to you to decide where is treatable or not.

Therefore you can study the incidents and I am at your disposal for any further information.

New Views of the past year (2011)

In the year 2011, three (3) Global Concentrations were performed in Europe where as a Representative of our country after accepting the invitation of Union Dermatologists that searching Vitiligo and melanoma, I attended the new developments of vitiligo treatment.

Therefore I shall provide my experiences to those interested about this social illness about the new data that really put some pieces of the puzzle into their proper place· but there are so many pieces are many and more effort needed in order to appear the entire picture of the ideal vitiligo treatment.

Research is made in many Vitiligo Research Centers in Italy-France-China-Korea-India and America where researchers’ objective is located.

1. The complete investigation of vitiligo pathogenesis.

2. The finding of a treatment with temporal effects (disadvantage of all treatments of 2010).

3. Patients protection from factors of disease extension.

4. Disease prevention and early diagnosis.

5 Guarantee of typical characteristics of a treatment (effective - not dangerous -painless - easy - low cost).

Epidemiology

Unfortunately there have been no international important epidemiological studies on vitiligo.

However, some studies carried out in the past few years, point to the conclusion that:

  • Vitiligo affects 0.5-4% of the World population.

  • The disease generally begins between the ages of 2 and 40.

  • In a Dutch study, 50% of patients reported the occurrence before the age of 20.

  • Incidence ranges from 0,1% to 8,8% in different country of the globe. The highest incidence of the condition has been recorded in India, Mexico and Japan.

  • Adults and children of both sex are equally affected

  • The greater number of reports among females is probably due to greater social consequence to woman and girls affected by this condition.

  • 50% of patients à before the age of 20

  • 25% of patients à before the age of 8

  • Incidence ranges from 0,1% to 8,8% in different country of the globe. The highest incidence of the condition has been recorded in India, Mexico and Japa

Classifications of epidemiological studies
  • Descriptive epidemiology (incidence, prevalence, HANES 1 study)

  • Analytical epidemiology (Factors, Relative risks, odds ratio)

  • Clinical epidemiology (Natural history and prognosys).

 

Koebner Phenomenon

Many announcements were made about Koebner phenomenon which was considered important for the development and the classification of vitiligo type.

What is Koebner? The skin of vitiligo patients is clinically physiologic, but histologically abnormal. Thus the continuous friction and injury increases the release of harmful neuropeptides that likely causing loss of melanocytes resulting in new lesions. Therefore this isomorphic (equal on both sides) skin reaction is the Koebner phenomenon.

 The three types of Koebner phenomenon were classified, with the second type being the most interesting because it subdivides in two forms.

1. The discoloration that is presented in friction areas (elbows - knees).

2. The discoloration in areas with chronic friction. Such as areas of chronic friction that related with the clothes, accessories, use of bathroom grater, earphone, sunscreen daily use, pc mouse, resulted in mechanical injury and new lesions.

 The human skin is exposed daily in a lot of environmental factors among these and the harmful effect of solar radiation that we avoid it with the correct use of sunshine.

Unfortunately the importance of mechanical injury is neglected and this involves the appearance of new lesions hence extension of vitiligo.

S. Moretti iccc 2011 Bordeaux – 22/9/2011

Vitiligo prevention in individuals with family history of vitiligo

Probably we have warning signs of vitiligo onset when:

• There is a family history of vitiligo.

• Permanent discoloration appears after children injury (scratches).

• There is halo naevi or Sutton nevus.

• There is coexistence of thyroid antibodies.

K Ezze dine - A. Diallo et all Br. J Dermatology 165(1):44 – 49 2011

Psychiatric Study

The psychiatric study concerned:

• Quality of life.

• Social parameters.

• Self-confidence.

• Stressful phenomena of vitiligo patients.



The study was conducted using specific questionnaires (as appropriate).

It was found according to quality of life and social parameters that the presence of autoimmune indicators was proportional to vitiligo surface, patients stress (interpersonal relations), their persistence and phobia.

Major priority was given to the good collaboration between patient and doctor for the correct effect of psychological interventions that concerns the quality of life and the interpersonal relations of vitiligo patients.

Taileb et all. Article first published online Mar 2009 10.1111.

 

A Message of Hope

The speech of a Negro patient who suffered from vitiligo impressed (there were days where vitiligo patients from all over the world were among the audience) and kept audience interest throughout his speech. At the end he tried to convince the vitiligo patients to live their life well.

Live Your Life Well (Lee Thomas)

I got the first spot of vitiligo on my scalp and just like a bad thought, it spread all over my body…..I didn’t know what to do, I was in despair. When I got the first diagnosis, I was some guy sitting in the park talking to him. Why me? Why did this happen now? What am I going to do now? I was struggling just to understand the Whys. Then I started to wonder what people saw when they were looking at me. Did they still see me normal? Or did they see a monster? Will they shake hands with me or they shall avoid eye contact with me? Shall I hide? It was hard. Then one day disasters turn into power. My weakness became my beauty. The contrast color was so amazing and terribly beautiful. Then I realize what people saw when they were looking at me…they saw a strong, proud, honest and sincere man. They saw a hard working man and a good citizen, a beloved neighbor, a brother, a son. They saw a good person standing proud. I knew that because they were looking at me.

Hello!! My name is Lee Thomas and my mission here is simple. I want to inspire you in order to live your life well. Because life: IS THE ULTIMATE GIFT. I have been travel all over the United States, speaking to groups of all classes recounting my situation. And is something beyond than a man’s story suffering from a devastating illness. We all have situations that we want to overcome. My story is a living example without limits. We all have something that we believe will hold us back…. that it will prevent our success.

Some are magnanimous others are pusillanimous. There are physical deformities of all forms and sizes. Some of them may be like mine, others remaining hidden. Whatever the reason, live your life to the fullest.

I stand here before you, a black man turning white, who goes on television (TV) every morning in front of hundreds of thousands of people, giving the example “live your dream”. I am here to let you know that everything is possible.

New proposals on vitiligo treatment

  1. Local treatment with prostagladines.

  2. Isotretinoin.

  3. Aspirin.

  4. Piper - Nigrum (Black pepper) in the form of cream, or oral use with or without phototherapy.

  5. Mixture of olive oil, corn oil, sunflower oil (rich in omega 3, omega 6) fatty acids, that involves free cortisol failure that acts competitively in vitamins D2-D3 that are low in vitiligo patients.

  6. Gene therapy.

  7. Hormonal therapy aiming to melanocytes stimulation.

  8. There weren’t any references on new lasers as previously given their low efficiency on vitiligo. Besides, laser therapy was proved time-consuming, expensive and disadvantageous and often dangerous since in all Vitiligo Centers worldwide is required patients signed consent before treatment onset with laser of low frequency.

  9. The antioxidant action of curcumin and capsaicin.

Finally it has been attempted for an international consent of data in the clinical research of vitiligo. Because on one hand the Japan - Taiwan team supported that whatever is vitiligo type the autoimmune mechanisms plays important role in vitiligo pathogenesis. For the team of Latin America important role play the genetic predisposition and the environmental factors on vitiligo pathogenesis. According to European opinion there is still vagueness about different pathogenesis for the two types of vitiligo.

Finally we can hope that in the very near future pieces of the puzzle will fall into the correct place for the appropriate vitiligo treatment.

Τελικά μπορούμε να ελπίζουμε ότι στο άμεσο μέλλον τα κομμάτια του παζλ θα μπουν στην σωστή θέση για την σωστή αντιμετώπιση της λεύκης.

(Source: Photographs are taken from Pigment Cell and Melanoma Magazine).


Is Vitiligo Curable? 

When we have to treat simple sciatica or any simple inflammation and we take medications usually the 10th day or the 15th day we are completely cured. Therefore vitiligo can’t be treated in fifteen (15) days.

If we take a look at the following 40 incidents that show the improvement of vitiligo in a 3 month or 5 month combined (local oral treatment) without laser – phototherapy (difficult, expensive or usually very dangerous treatments) then it’s up to you to decide where is treatable or not.

Therefore you can study the incidents and I am at your disposal for any further information.

New Views of the past year (2011)

In the year 2011, three (3) Global Concentrations were performed in Europe where as a Representative of our country after accepting the invitation of Union Dermatologists that searching Vitiligo and melanoma, I attended the new developments of vitiligo treatment.

Therefore I shall provide my experiences to those interested about this social illness about the new data that really put some pieces of the puzzle into their proper place· but there are so many pieces are many and more effort needed in order to appear the entire picture of the ideal vitiligo treatment.

Research is made in many Vitiligo Research Centers in Italy-France-China-Korea-India and America where researchers’ objective is located.

1. The complete investigation of vitiligo pathogenesis.

2. The finding of a treatment with temporal effects (disadvantage of all treatments of 2010).

3. Patients protection from factors of disease extension.

4. Disease prevention and early diagnosis.

5 Guarantee of typical characteristics of a treatment (effective - not dangerous -painless - easy - low cost).

Epidemiology

Unfortunately there have been no international important epidemiological studies on vitiligo.

However, some studies carried out in the past few years, point to the conclusion that:

  • Vitiligo affects 0.5-4% of the World population.

  • The disease generally begins between the ages of 2 and 40.

  • In a Dutch study, 50% of patients reported the occurrence before the age of 20.

  • Incidence ranges from 0,1% to 8,8% in different country of the globe. The highest incidence of the condition has been recorded in India, Mexico and Japan.

  • Adults and children of both sex are equally affected

  • The greater number of reports among females is probably due to greater social consequence to woman and girls affected by this condition.

  • 50% of patients à before the age of 20

  • 25% of patients à before the age of 8

  • Incidence ranges from 0,1% to 8,8% in different country of the globe. The highest incidence of the condition has been recorded in India, Mexico and Japa

Classifications of epidemiological studies
  • Descriptive epidemiology (incidence, prevalence, HANES 1 study)

  • Analytical epidemiology (Factors, Relative risks, odds ratio)

  • Clinical epidemiology (Natural history and prognosys).

 

Koebner Phenomenon

Many announcements were made about Koebner phenomenon which was considered important for the development and the classification of vitiligo type.

What is Koebner? The skin of vitiligo patients is clinically physiologic, but histologically abnormal. Thus the continuous friction and injury increases the release of harmful neuropeptides that likely causing loss of melanocytes resulting in new lesions. Therefore this isomorphic (equal on both sides) skin reaction is the Koebner phenomenon.

 The three types of Koebner phenomenon were classified, with the second type being the most interesting because it subdivides in two forms.

1. The discoloration that is presented in friction areas (elbows - knees).

2. The discoloration in areas with chronic friction. Such as areas of chronic friction that related with the clothes, accessories, use of bathroom grater, earphone, sunscreen daily use, pc mouse, resulted in mechanical injury and new lesions.

 The human skin is exposed daily in a lot of environmental factors among these and the harmful effect of solar radiation that we avoid it with the correct use of sunshine.

Unfortunately the importance of mechanical injury is neglected and this involves the appearance of new lesions hence extension of vitiligo.

S. Moretti iccc 2011 Bordeaux – 22/9/2011

Vitiligo prevention in individuals with family history of vitiligo

Probably we have warning signs of vitiligo onset when:

• There is a family history of vitiligo.

• Permanent discoloration appears after children injury (scratches).

• There is halo naevi or Sutton nevus.

• There is coexistence of thyroid antibodies.

K Ezze dine - A. Diallo et all Br. J Dermatology 165(1):44 – 49 2011

Psychiatric Study

The psychiatric study concerned:

• Quality of life.

• Social parameters.

• Self-confidence.

• Stressful phenomena of vitiligo patients.



The study was conducted using specific questionnaires (as appropriate).

It was found according to quality of life and social parameters that the presence of autoimmune indicators was proportional to vitiligo surface, patients stress (interpersonal relations), their persistence and phobia.

Major priority was given to the good collaboration between patient and doctor for the correct effect of psychological interventions that concerns the quality of life and the interpersonal relations of vitiligo patients.

Taileb et all. Article first published online Mar 2009 10.1111.

 

A Message of Hope

The speech of a Negro patient who suffered from vitiligo impressed (there were days where vitiligo patients from all over the world were among the audience) and kept audience interest throughout his speech. At the end he tried to convince the vitiligo patients to live their life well.

Live Your Life Well (Lee Thomas)

I got the first spot of vitiligo on my scalp and just like a bad thought, it spread all over my body…..I didn’t know what to do, I was in despair. When I got the first diagnosis, I was some guy sitting in the park talking to him. Why me? Why did this happen now? What am I going to do now? I was struggling just to understand the Whys. Then I started to wonder what people saw when they were looking at me. Did they still see me normal? Or did they see a monster? Will they shake hands with me or they shall avoid eye contact with me? Shall I hide? It was hard. Then one day disasters turn into power. My weakness became my beauty. The contrast color was so amazing and terribly beautiful. Then I realize what people saw when they were looking at me…they saw a strong, proud, honest and sincere man. They saw a hard working man and a good citizen, a beloved neighbor, a brother, a son. They saw a good person standing proud. I knew that because they were looking at me.

Hello!! My name is Lee Thomas and my mission here is simple. I want to inspire you in order to live your life well. Because life: IS THE ULTIMATE GIFT. I have been travel all over the United States, speaking to groups of all classes recounting my situation. And is something beyond than a man’s story suffering from a devastating illness. We all have situations that we want to overcome. My story is a living example without limits. We all have something that we believe will hold us back…. that it will prevent our success.

Some are magnanimous others are pusillanimous. There are physical deformities of all forms and sizes. Some of them may be like mine, others remaining hidden. Whatever the reason, live your life to the fullest.

I stand here before you, a black man turning white, who goes on television (TV) every morning in front of hundreds of thousands of people, giving the example “live your dream”. I am here to let you know that everything is possible.

New proposals on vitiligo treatment

  1. Local treatment with prostagladines.

  2. Isotretinoin.

  3. Aspirin.

  4. Piper - Nigrum (Black pepper) in the form of cream, or oral use with or without phototherapy.

  5. Mixture of olive oil, corn oil, sunflower oil (rich in omega 3, omega 6) fatty acids, that involves free cortisol failure that acts competitively in vitamins D2-D3 that are low in vitiligo patients.

  6. Gene therapy.

  7. Hormonal therapy aiming to melanocytes stimulation.

  8. There weren’t any references on new lasers as previously given their low efficiency on vitiligo. Besides, laser therapy was proved time-consuming, expensive and disadvantageous and often dangerous since in all Vitiligo Centers worldwide is required patients signed consent before treatment onset with laser of low frequency.

  9. The antioxidant action of curcumin and capsaicin.

Finally it has been attempted for an international consent of data in the clinical research of vitiligo. Because on one hand the Japan - Taiwan team supported that whatever is vitiligo type the autoimmune mechanisms plays important role in vitiligo pathogenesis. For the team of Latin America important role play the genetic predisposition and the environmental factors on vitiligo pathogenesis. According to European opinion there is still vagueness about different pathogenesis for the two types of vitiligo.

Finally we can hope that in the very near future pieces of the puzzle will fall into the correct place for the appropriate vitiligo treatment.

Τελικά μπορούμε να ελπίζουμε ότι στο άμεσο μέλλον τα κομμάτια του παζλ θα μπουν στην σωστή θέση για την σωστή αντιμετώπιση της λεύκης.

(Source: Photographs are taken from Pigment Cell and Melanoma Magazine).



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